Person

Barry T Rouse

Institute Professor | Biomedical and Diagnostic Sciences Department
Overview

My research is in the field of infectious disease and has focused on viral immunology and immunopathology. We have mainly studied herpes simplex virus (HSV) infection in mice both with a view to devising successful vaccines and more particularly to determine how HSV causes tissue damage in critical tissues such as the eye and nervous system. We have worked on both host innate and adaptive immune mechanisms, particularly the T cells responsible for immunity as well as those involved in orchestrating tissue damage. We have defined the role of several subtypes of proinflammatory T cells as well as numerous cytokines and chemokines. Our group was the first to show a role of regulatory T cells (Treg) in the host response to a virus infection. We demonstrated that Treg responses could act to inhibit the efficiency of immunity, but that Treg were valuable to modulate the severity of immunopathological responses, such as those that occur in the corneal stroma after HSV infection of the eye.

Teaching Focus

Immunology

Courses
Below are courses taught during the current or past three academic years. Consult Timetable for the most current listing of courses and instructor(s).
CEM 515 - Current Topics in Comparative and Experimental Medicine
1 - 6 credit hours

Specialized experience in comparative and experimental medicine.

Repeatability: May be repeated. Maximum 12 hours.
Registration Permission: Consent of instructor.

Other Instructors: Collar, Elizabeth Marie | Abouelkhair, Mohamed | Sultana, Hameeda

CEM 612 - Journal Club in Biomedical and Diagnostic Sciences
1 credit hour(s)

Readings and discussions based on current literature.

Repeatability: May be repeated. Maximum 12 hours.
Registration Restriction(s): Minimum student level – graduate.

Other Instructors: Schaefer, Deanna M | Giori, Luca | Lear, Andrea Sketch | Whitlock, Brian Keith | Neelakanta, Girish | Smith, Joe | Anderson, David Edgar | Reed Jr, Robert B | Caldwell, Marc | Sheldon, Julie Deanne | Gerhold Jr, Richard William | Cushing, Andrew | Dhar, Madhu S

CEM 620 - Current Topics in Comparative and Experimental Medicine
1 - 3 credit hours

Specialized, in-depth experience in various disciplines, such as current and future research methodology, and recent advances in instrumentation in analytical techniques for comparative medicine.

Repeatability: May be repeated. Maximum 12 hours.
Registration Restriction(s): Minimum student level – graduate.

Other Instructors: Tobias, Karen M | Flatland, Bente | Whitlock, Brian Keith

Picture of Barry T Rouse
512 Ken and Blaire Mossman Building
1311 Cumberland Avenue
Knoxville, TN 37996
Education and Training
  • Doctorate, Veterinary Medicine, General, Other, 1970

Barry T Rouse

Institute Professor | Biomedical and Diagnostic Sciences Department
Picture of Barry T Rouse image
512 Ken and Blaire Mossman Building
1311 Cumberland Avenue
Knoxville, TN 37996
Education and Training
  • Doctorate, Veterinary Medicine, General, Other, 1970
Overview

My research is in the field of infectious disease and has focused on viral immunology and immunopathology. We have mainly studied herpes simplex virus (HSV) infection in mice both with a view to devising successful vaccines and more particularly to determine how HSV causes tissue damage in critical tissues such as the eye and nervous system. We have worked on both host innate and adaptive immune mechanisms, particularly the T cells responsible for immunity as well as those involved in orchestrating tissue damage. We have defined the role of several subtypes of proinflammatory T cells as well as numerous cytokines and chemokines. Our group was the first to show a role of regulatory T cells (Treg) in the host response to a virus infection. We demonstrated that Treg responses could act to inhibit the efficiency of immunity, but that Treg were valuable to modulate the severity of immunopathological responses, such as those that occur in the corneal stroma after HSV infection of the eye.

Teaching Focus

Immunology

Courses
Below are courses taught during the current or past three academic years. Consult Timetable for the most current listing of courses and instructor(s).
CEM 515 - Current Topics in Comparative and Experimental Medicine
1 - 6 credit hours

Specialized experience in comparative and experimental medicine.

Repeatability: May be repeated. Maximum 12 hours.
Registration Permission: Consent of instructor.

Other Instructors: Collar, Elizabeth Marie | Abouelkhair, Mohamed | Sultana, Hameeda

CEM 612 - Journal Club in Biomedical and Diagnostic Sciences
1 credit hour(s)

Readings and discussions based on current literature.

Repeatability: May be repeated. Maximum 12 hours.
Registration Restriction(s): Minimum student level – graduate.

Other Instructors: Schaefer, Deanna M | Giori, Luca | Lear, Andrea Sketch | Whitlock, Brian Keith | Neelakanta, Girish | Smith, Joe | Anderson, David Edgar | Reed Jr, Robert B | Caldwell, Marc | Sheldon, Julie Deanne | Gerhold Jr, Richard William | Cushing, Andrew | Dhar, Madhu S

CEM 620 - Current Topics in Comparative and Experimental Medicine
1 - 3 credit hours

Specialized, in-depth experience in various disciplines, such as current and future research methodology, and recent advances in instrumentation in analytical techniques for comparative medicine.

Repeatability: May be repeated. Maximum 12 hours.
Registration Restriction(s): Minimum student level – graduate.

Other Instructors: Tobias, Karen M | Flatland, Bente | Whitlock, Brian Keith