My professional interest is to use molecular/genetic/genomics tools to understand bacterial pathogenesis, drug resistance, and identify potential targets of novel intervention strategies (e.g., vaccination) and diagnostic tools. In the past, by taking traditional and modern molecular and genetic/genomics approaches I studied the biology of Campylobacter jejuni, an leading foodborne human pathogen, and the colistin resistance in Escherichia coli. I focused on the mechanisms for the development and transfer of antibiotic resistance, the molecular basis of iron-acquisition system, and evaluation of several innovative intervention strategies (such as enterobactin vaccine) to control bacterial infections in food animals. I hope to expand their application to the diagnosis of host gut health. I have been working on physiological effects of modulation of interestinal microbiome by exploring the effects and mechanisms of antibiotic growth promoter.